Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal
Background Bicuspid aortic valve (BAV) is a congenital cardiac deformity, increasing the risk of developing calcific aortic valve disease (CAVD).The disturbance of FOOT REFRESH hemodynamics can induce valvular calcification, but the mechanism has not been fully identified.Methods We constructed a finite element model (FEM) of the aortic valve based